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The Impact of Oral Isotretinoin Dryness and Depression on Saudi Women in Qassim Region: A Survey

Salwa Al-Suhaibani

Background: Oral Isotretinoin is the most effective choice in the treatment of severe acne. There are relationship between the use of Isotretinoin and depression and dryness.

Objectives: To assess the impact of oral Isotretinoin dryness and depression on saudi women in Qassim Region. Method: This non-interventional cross-sectional survey was conducted between October 13 to November 8, 2015 in acne patients from the Qassim region. Online-based questionnaire used as study tool. The filled questionnaires were analyzed using SPSS version 21.

Result: A sample of 202 participants were obtained, most of them were of age group 18-25 years old [(75.7%). About 6% of females used the drug without consult the doctor. Only (28.2%) of participants did not suffer from side effect. Large number of participant said that they have crying episode during the treatment (about 27% of the participants). Almost all participants 198 females (98%) suffer from dryness. Seventeen percent of participants discontinue the treatment because of side effects.

Conclusion: Considerable number of Isotretinoin treated patients showed deferent signs of depression and this supports the association of Isotretinoin and depression. The dryness which is the major side effects of Isotretinoin appear in almost all females treated with Isotretinoin. No correlation found between dryness and any sign of depression.