कार्बनिक रसायन विज्ञान: वर्तमान अनुसंधान
खुला एक्सेस

अमूर्त

कोर यूनिट के रूप में थिएनो [2,3-डी] पाइरीमिडीन से व्युत्पन्न कुछ नवीन हेटरोसाइक्लिक अणुओं का संश्लेषण, संरचनात्मक स्पष्टीकरण और जीवाणुरोधी मूल्यांकन

विरुपाक्षी प्रभाकर, संगु जगदीश बाबू, संगु वीएन ललिता शिव ज्योति, संगु वीएन लहरी, वेंकटेश्वरलू बंदी

A series of novel 4-(3,5-dimethyl-1H-pyrazol-1-yl)-2-substituted phenyl/Heterocyclic Thieno[2,3-d] Pyrimidine (8 a-j) derivatives were synthesized by a facile Five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. The structures of the final compounds were confirmed by IR, NMR, EI-MS. The final compounds were screened for their anti-bacterial activity against Bacillus subtilis and Staphylocouccus aureus from Gram positive group of bacteria and Escherichia coli and Klebsiella pneumonia from Gram negative group of bacteria and antifungal activity against Candida albicans and Aspergillus flavus. Anti-bacterial and anti-fungal activities were Evaluated and compared with the standard drugs Such as Amoxicillin and Ketoconazole. From anti-bacterial and antifungal activity screening results, it has been observed that compounds 8i, 8h, 8e and 8j possess good activity.