थर्मोडायनामिक्स और कैटलिसिस जर्नल
खुला एक्सेस

अमूर्त

Oxidation of Tricyclic Antidepressant Agent, Amitriptyline, by Permanganate in Sulphuric Acid Medium: Kinetic and Mechanistic Approach

Shekappa D. Lamani and Sharanappa T. Nandibewoor

The kinetics of oxidation of amitriptyline by potassium permanganate in aqueous sulphuric acid medium at 298K and at a constant ionic strength of 0.20 mol dm-3 has been investigated spectrophotometrically. The reaction exhibits 5:4 stoichiometry (5 Amitriptyline:4 KMnO4). The reaction was first order with respect to manganese(VII) concentration. The order with respect to amitriptyline was found to be less than unity (0.80). Increase in acid concentration increased the rate. The order with respect to acid concentration was also less than unity (0.40). The effect of added products, ionic strength and dielectric constant have been studied on the rate of reaction. The oxidation products were identified by using 2,4 DNP derivative, IR, GCMS spectral studies. A suitable mechanism was proposed on the basis of experimental results. The reaction constants involved in the different steps of the reaction mechanism were calculated. The activation parameters with respect to slow step of the mechanism was determined and discussed.