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Do Moonlighting Proteins Belong to the Intrinsically Disordered Protein Class?

Sergio Hernández, Isaac Amela, Juan Cedano, Jaume Piñol, JosepAntoni Perez-Pons, Angel Mozo-Villarias and Enrique Querol

Moonlighting is the capability of some proteins to execute two or more biological functions. According to some authors, there is a relationship between protein conformational fluctuations and promiscuous functions of proteins. This promiscuity would be due to the conformational properties of the structurally disordered regions. To check if moonlighting proteins belong to the Intrinsically Disordered Protein (IDP) class, we have predicted IDP/IDR (Intrinsically Disordered Regions) for a number of moonlighting proteins. Our results suggest that most moonlighting proteins do not belong to the IDP class.