जर्नल ऑफ ड्रग मेटाबॉलिज्म एंड टॉक्सिकोलॉजी
खुला एक्सेस

अमूर्त

Administration of Cannabinol and Alcohol Altered the Liver Enzymes, Lipid Profile and Antioxidant Status of Male Wistar Rats

Akintayo C.O1, Olukiran O.S2*, Ayodele M.J3, Karga S.V3

Background: Cannabis and alcohol increasingly gain legalized status in many countries, the popularity and prevalence of use continues to grow.

Objective: This study was designed to investigate their effects on liver enzymes and lipid profile of rats.

Methods: Twenty five male rats were divided into 5 groups; group 1 was given distilled water; groups 2, 3, 4 and 5 rats were treated with 5% methanol, 25% alcohol, 10 mg/kg of cannabinol, 25% alcohol and 10 mg/kg of cannabinol p.o for 8 weeks respectively. Statistical analysis was done using the ANOVA.

Results: The serum concentrations of AST and ALT were significantly higher in groups 3, 4 and 5 when compared with groups 1 and 2. Groups 1 and 2 had LDL and HDL that were significantly lower than that of groups 3 and 4. Rats in group 5 had HDL that was significantly higher compared to group 1. The total cholesterol level of groups 3, 4 and 5 was significantly higher than that of groups 1 and 2. However, the rats in group 5 had total cholesterol level that was significantly lower when compared with groups 3 and 4. Groups 3, 4 and 5 had triglycerides concentration in the plasma that was significantly higher than that of groups 1 and 2. The photomicrographs of groups 3, 4 showed signs of dilated sinusoids when compared with groups 1 and 2.

Conclusion: It was concluded that the administration of alcohol and cannabinol altered the liver enzymes, lipid profile and antioxidant status of male rats.